Achieving self reliance through “Atmanirbhar Bharat” and Make in India have been in place for a reasonable time and yielding results. Now collaboration among academic , research institutes , start-ups and industry has to be accelerated for focused development of indigenized technologies in the country. Knowledge sharing among these stakeholders is very important as Research and applied research are the key ingredients for ensuring the success of any project/product. Collaboration is to leverage on the expertise of others and accomplish a given task much quicker. Delivery can be in terms of High impact research publications, Patents & IPRs, Large Scale projects, World Class Products and solutions. Relevance of Indigenization is much more relevant now as several sectors are affected in India by supply chain constraints in international market due to Covid19 and Russia -Ukraine conflict. Indigenization is important in strategic sector, medical field, cyber security and data protection. In addition to protecting national interests, savings in foreign reserve and more job opportunities for local people are major goals of indigenization. It is pertinent that indigenous technologies play vital role in strengthening the strategic sector for the future. C-DAC has developed many systems of strategic importance to the nation’s Internal Security, Space, Health, Cyber forensics, Communications, Microprocessor development and Atomic Energy programmes with features like interoperability, resilience, scalability, modularity and robustness. C-DAC’s success stories in developing prototypes and translating it into commercial products will also be covered in the webinar.